BioNetwork West 2015 (past event)

October 26 - 28, 2015

Contact Us: 1.888.482.6012

Neil Desai, Founder/CEO at AADi, LLC
AADi, LLC Logo

Neil Desai


Founder/CEO
AADi, LLC

Check out the incredible speaker line-up to see who will be joining Neil.

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Innovative Dealmaking

Friday, February 10th, 2017


12:20 Biotech Spotlight: AADi, an NCI STTR-funded company

AADi, an NCI STTR-funded company was founded by Dr. Neil Desai in 2011 to develop a targeted mTOR therapeutic based on the highly successful ‘nab’ nanoparticle albumin bound technology originally developed by Dr. Desai at Abraxis Bioscience. AADi’s first product, ABI-009, albumin-bound sirolimus (nab-rapamycin), a highly active form of sirolimus with nanoparticles of 100 nm coated with albumin, is based on the same technology as Abraxane® (nab-paclitaxel, Abraxis Bioscience, acquired by Celgene Corp in 2010 for ~$3B, 2015 est sales ~$1B). ABI-009 has a superior clinical and pharmacological profile compared to any other mTOR inhibitor. A phase 1 trial in patients with solid tumors showed promising safety and evidence of activity. Unlike other mTOR inhibitors, ABI-009 is being developed in highly select populations with diseases driven by mTOR activation that represent sizeable market opportunities. AADi is investigating the use of ABI-009 in a number of solid tumors and will initiate a registration study in a rare sarcoma in 2015. Through a NIH Fast-Track STTR grant, ABI-009 is being investigated in phase 1/2 trials for BCG-refractory bladder cancer. AADi also plans to initiate clinical studies in treatment of advanced pulmonary hypertension as well for treatment of rare pediatric cancers. AADi is currently in the process of raising capital to fund these opportunities.